Disease intervention specialists (DIS) play a critical role in partner notification, counseling, and referral services for HIV and other sexually transmitted diseases (STDs); and such programs are integral components of HIV/STD prevention activities by state and local health departments. With rising rates of STDs, emerging infections such as COVID-19, and an evolving role of DIS, numerous questions can be addressed through economic analysis such as quantifying the return on investment of DIS activities, determining the budget requirements to deliver partner services to all eligible populations, or developing a prioritization model for allocating DIS resources. This two-phase project will include both a systematic literature review of the existing evidence on the costs and outcomes of DIS and partner services across diseases and an economic analysis.