Despite advances in prevention and treatment, significant disparities still exist in rates of HIV and sexually transmitted infections (STIs) in the United States. The root causes of these disparities are social determinants of health (e.g., pervasive stigma, lack of access to quality health care, housing insecurity). The purpose of this project is to take the first step towards quantifying the potential benefits of addressing social determinates of health (SDoH) and reducing disparities. The project aims to estimate the potential benefits, in terms of infections averted, that can be achieved by closing some of the gaps in HIV and STI disparities among priority racial/ethnic minority populations.