While TB transmission rates have declined nationally in the United States during the last two decades – owing largely to TB control efforts – responding to TB outbreaks (which often occur among people experiencing homelessness or incarceration) to prevent further transmission, remains an important priority for TB control. This project will collaborate closely with DTBE and state-level TB controllers to develop TB outbreak models in the US. These proposed models will focus on large TB outbreaks and aim to estimate the epidemiological impact and cost-effectiveness of TB outbreak response in the US.