HIV, viral hepatitis, STIs, and tuberculosis remain critical threats to the public’s health in the United States. With millions of people estimated to be living with these infections – many of whom may be unaware of their infection - successful implementation of routine screening and linkage to care for HIV, viral hepatitis, STIs, and TB are critical. This project aims to use mathematical modeling to explore the implementation of integrated screening to identify the most impactful and cost-effective routine screening interventions in clinical settings for HIV, viral hepatitis, STIs, and TB under a prescribed set of scenarios.