Over the past decade, acute HCV incidence rates have been increasing and are highest among adults of reproductive age. As a result, the number of infants with perinatal exposure to HCV is also increasing. Neither CDC nor USPSTF have published testing recommendations for infants perinatally exposed to HCV and other recommendations from medical organizations are inconsistent and confusing for clinicians – leading to a lack of testing among HCV-exposed children and resulting in many undiagnosed pediatric HCV infections. This project's objective is to use an economic analysis framework to identify the optimal testing strategy for infants born to HCV-infected mothers.